SMALL MOLECULE INHIBITORS OF CRM1

Small Molecule Inhibitors of CRM1

The APRICOT GOLD transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms.Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal expression of CRM1 is oncogenic.Inhibition of CRM1 has long been postulated as poten

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The changing epidemiology of measles in an era of elimination: lessons from health-care-setting transmissions of measles during an outbreak in New South Wales, Australia, 2012

Introduction: In countries where measles is rare, health-care-setting transmissions remain problematic.Australia experienced its largest measles outbreak in 15 years in 2012 with 199 cases reported nationally; 170 cases occurred in the state of New South Wales (NSW) with symptom onset between 7 April and 29 November 2012.Methods: A descriptive stud

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